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A novel interaction between megakaryocytes and activated fibrocytes increases TGF-β bioavailability in the Gata1(low) mouse model of myelofibrosis

Despite numerous circumstantial evidences, the pathogenic role of TGF-β in primary myelofibrosis (PMF), the most severe of the Philadelphia-negative myeloproliferative neoplasms, is still unclear because of the modest (2-fold) increases in its plasma levels observed in PMF patients and in the Gata1(...

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Detalhes bibliográficos
Publicado no:Am J Blood Res
Main Authors: Zingariello, Maria, Ruggeri, Alessandra, Martelli, Fabrizio, Marra, Manuela, Sancillo, Laura, Ceglia, Ilaria, Rana, Rosa Alba, Migliaccio, Anna Rita
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769347/
https://ncbi.nlm.nih.gov/pubmed/27069753
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