Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk

AKI with incomplete epithelial repair is a major contributor to CKD characterized by tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is hypothesized to underlie this link, but the identity of these factors and whether epithelial injury is required remain undef...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Main Authors: Maarouf, Omar H., Aravamudhan, Anusha, Rangarajan, Deepika, Kusaba, Tetsuro, Zhang, Victor, Welborn, Jeremy, Gauvin, Daniel, Hou, Xiuyun, Kramann, Rafael, Humphreys, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2016
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769196/
https://ncbi.nlm.nih.gov/pubmed/26204899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014121188
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