Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk

AKI with incomplete epithelial repair is a major contributor to CKD characterized by tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is hypothesized to underlie this link, but the identity of these factors and whether epithelial injury is required remain undef...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Maarouf, Omar H., Aravamudhan, Anusha, Rangarajan, Deepika, Kusaba, Tetsuro, Zhang, Victor, Welborn, Jeremy, Gauvin, Daniel, Hou, Xiuyun, Kramann, Rafael, Humphreys, Benjamin D.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2016
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769196/
https://ncbi.nlm.nih.gov/pubmed/26204899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014121188
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