Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin.

Endotoxin stimulates leukocytes to release cytokines that initiate septic shock in humans and animals. CD14, a glycosyl-phosphatidylinositol-anchored membrane glycoprotein, is an endotoxin receptor on leukocytes, and endotoxin binding to CD14 induces cytokine production. Here we show that glycosyl-p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lee, J D, Kravchenko, V, Kirkland, T N, Han, J, Mackman, N, Moriarty, A, Leturcq, D, Tobias, P S, Ulevitch, R J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7694296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.21.9930
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