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A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk and HPV-positive tumors of oropharyngeal cancer
BACKGROUND: Genetic polymorphisms in the 3′ UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. An insertion (Ins)/deletion (Del) polymorphism (rs3783553) in the 3′ UTR of IL-1α may disrupt a binding site for miRNA-122. IL-1α plays...
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| Publié dans: | Eur J Cancer |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4768464/ https://ncbi.nlm.nih.gov/pubmed/25981582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2015.04.016 |
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