A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk and HPV-positive tumors of oropharyngeal cancer

BACKGROUND: Genetic polymorphisms in the 3′ UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. An insertion (Ins)/deletion (Del) polymorphism (rs3783553) in the 3′ UTR of IL-1α may disrupt a binding site for miRNA-122. IL-1α plays...

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I publikationen:Eur J Cancer
Huvudupphovsmän: Zhang, Yang, Sturgis, Erich.M., Sun, Yan, Sun, Chuanzheng, Wei, Qingyi, Huang, Zhigang, Li, Guojun
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768464/
https://ncbi.nlm.nih.gov/pubmed/25981582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2015.04.016
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