Mechanical prophylaxis is a heparin-independent risk for anti–platelet factor 4/heparin antibody formation after orthopedic surgery

Platelet-activating antibodies, which recognize platelet factor 4 (PF4)/heparin complexes, induce spontaneous heparin-induced thrombocytopenia (HIT) syndrome or fondaparinux-associated HIT without exposure to unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). This condition mostly...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bito, Seiji, Miyata, Shigeki, Migita, Kiyoshi, Nakamura, Mashio, Shinohara, Kazuhito, Sato, Tomotaro, Tonai, Takeharu, Shimizu, Motoyuki, Shibata, Yasuhiro, Kishi, Kazuhiko, Kubota, Chikara, Nakahara, Shinnosuke, Mori, Toshihito, Ikeda, Kazuo, Ota, Shusuke, Minamizaki, Takeshi, Yamada, Shigeru, Shiota, Naofumi, Kamei, Masataka, Motokawa, Satoru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768427/
https://ncbi.nlm.nih.gov/pubmed/26659923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-651620
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