Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

BACKGROUND: Endogenous defense against oxidative stress is controlled by nuclear factor erythroid 2-related factor 2 (Nrf2). The normal compensatory mechanisms to combat oxidative stress appear to be insufficient to protect against the prolonged exposure to reactive oxygen species during disease. Co...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Liddell, Jeffrey R., Lehtonen, Sarka, Duncan, Clare, Keksa-Goldsteine, Velta, Levonen, Anna-Liisa, Goldsteins, Gundars, Malm, Tarja, White, Anthony R., Koistinaho, Jari, Kanninen, Katja M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768425/
https://ncbi.nlm.nih.gov/pubmed/26920699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0515-9
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