Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors

OBJECTIVE: This study was conducted to characterize the effects of food on single-dose pharmacokinetics (PK) of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in patients with advanced solid tumors. METHODS: Following overnight fasting for 10 h, a single 50 mg enteric-coated table...

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Publicat a:Drugs R D
Autors principals: Falchook, Gerald S., Zhou, Xiaofei, Venkatakrishnan, Karthik, Kurzrock, Razelle, Mahalingam, Devalingam, Goldman, Jonathan W., Jung, JungAh, Ullmann, Claudio Dansky, Milch, Catherine, Rosen, Lee S., Sarantopoulos, John
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2015
Matèries:
Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767718/
https://ncbi.nlm.nih.gov/pubmed/26689566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-015-0114-8
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