Integrative approaches for large-scale transcriptome-wide association studies

Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance levels of one or multiple proteins. Here, we introduce a powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide associati...

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Udgivet i:Nat Genet
Main Authors: Gusev, Alexander, Ko, Arthur, Shi, Huwenbo, Bhatia, Gaurav, Chung, Wonil, Penninx, Brenda W J H, Jansen, Rick, de Geus, Eco JC, Boomsma, Dorret I, Wright, Fred A, Sullivan, Patrick F, Nikkola, Elina, Alvarez, Marcus, Civelek, Mete, Lusis, Aldons J., Lehtimäki, Terho, Raitoharju, Emma, Kähönen, Mika, Seppälä, Ilkka, Raitakari, Olli T., Kuusisto, Johanna, Laakso, Markku, Price, Alkes L., Pajukanta, Päivi, Pasaniuc, Bogdan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767558/
https://ncbi.nlm.nih.gov/pubmed/26854917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3506
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