Integrative approaches for large-scale transcriptome-wide association studies

Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance levels of one or multiple proteins. Here, we introduce a powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide associati...

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Bibliografski detalji
Izdano u:Nat Genet
Glavni autori: Gusev, Alexander, Ko, Arthur, Shi, Huwenbo, Bhatia, Gaurav, Chung, Wonil, Penninx, Brenda W J H, Jansen, Rick, de Geus, Eco JC, Boomsma, Dorret I, Wright, Fred A, Sullivan, Patrick F, Nikkola, Elina, Alvarez, Marcus, Civelek, Mete, Lusis, Aldons J., Lehtimäki, Terho, Raitoharju, Emma, Kähönen, Mika, Seppälä, Ilkka, Raitakari, Olli T., Kuusisto, Johanna, Laakso, Markku, Price, Alkes L., Pajukanta, Päivi, Pasaniuc, Bogdan
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767558/
https://ncbi.nlm.nih.gov/pubmed/26854917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3506
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