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Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents

Kv7 (KCNQ) channels, formed as homo- or heterotetramers of Kv7.4 and Kv7.5 α-subunits, are important regulators of vascular smooth muscle cell (VSMC) membrane voltage. Recent studies demonstrate that direct pharmacological modulation of VSMC Kv7 channel activity can influence blood vessel contractil...

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Publicat a:Mol Pharmacol
Autors principals: Mani, Bharath K., Robakowski, Christina, Brueggemann, Lyubov I., Cribbs, Leanne L., Tripathi, Abhishek, Majetschak, Matthias, Byron, Kenneth L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767407/
https://ncbi.nlm.nih.gov/pubmed/26700561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.101758
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