Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis

Selenium is a trace element that is essential for human health and is incorporated into more than 25 human selenocysteine-containing (Sec-containing) proteins via unique Sec-insertion machinery that includes a specific, nuclear genome–encoded, transfer RNA (tRNA([Ser]Sec)). Here, we have identified...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Schoenmakers, Erik, Carlson, Bradley, Agostini, Maura, Moran, Carla, Rajanayagam, Odelia, Bochukova, Elena, Tobe, Ryuta, Peat, Rachel, Gevers, Evelien, Muntoni, Francesco, Guicheney, Pascale, Schoenmakers, Nadia, Farooqi, Sadaf, Lyons, Greta, Hatfield, Dolph, Chatterjee, Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767355/
https://ncbi.nlm.nih.gov/pubmed/26854926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84747
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