Intraarterial Microdosing, a Novel Drug Development Approach, Proof-of-Concept PET Study in Rats

Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure similar to that of systemic full-dose administration but with minimal systemic exposure. IAM could enable the safe, in...

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Bibliografiske detaljer
Udgivet i:J Nucl Med
Main Authors: Burt, Tal, Rouse, Douglas C., Lee, Kihak, Wu, Huali, Layton, Anita T., Hawk, Thomas C., Weitzel, Douglas H., Chin, Bennett B., Cohen-Wolkowiez, Michael, Chow, Shein-Chung, Noveck, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767259/
https://ncbi.nlm.nih.gov/pubmed/26315828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.115.160986
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