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An Insulin-Like Growth Factor-1 (IGF-1)/Insulin Receptor Substrate-1 (IRS-1) Pathway Stimulates a Mitotic Kinase (cdk1) in the Uterine Epithelium During the Proliferative Response to Estradiol
Estrogens are potent mitogens for some target organs, such as the uterus, and cancers that develop in this organ might be linked to the proliferative action of these hormones. However, the mechanism by which estrogens influence the cell cycle machinery is not known. We found that a null mutation for...
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| Published in: | J Endocrinol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4766979/ https://ncbi.nlm.nih.gov/pubmed/20798132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0102 |
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