An Insulin-Like Growth Factor-1 (IGF-1)/Insulin Receptor Substrate-1 (IRS-1) Pathway Stimulates a Mitotic Kinase (cdk1) in the Uterine Epithelium During the Proliferative Response to Estradiol

Estrogens are potent mitogens for some target organs, such as the uterus, and cancers that develop in this organ might be linked to the proliferative action of these hormones. However, the mechanism by which estrogens influence the cell cycle machinery is not known. We found that a null mutation for...

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Bibliografische gegevens
Gepubliceerd in:J Endocrinol
Hoofdauteurs: Walker, Michael P., DiAugustine, Richard P., Zeringue, Ernest, Bunger, Maureen K., Schmitt, Martina, Archer, Trevor K., Richards, R. Gregg
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766979/
https://ncbi.nlm.nih.gov/pubmed/20798132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0102
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