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Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner

We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and progesterone (P4) are essential for this response. However, to what extent testosterone may also contribute, and whether durat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Saland, Samantha K., Schoepfer, Kristin J., Kabbaj, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766854/
https://ncbi.nlm.nih.gov/pubmed/26888470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21322
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