Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics

The three canonical Rho GTPases RhoA, Rac1 and Cdc42 co-ordinate cytoskeletal dynamics. Recent studies indicate that all three Rho GTPases are activated at the leading edge of motile fibroblasts, where their activity fluctuates at subminute time and micrometer length scales. Here, we use a microflui...

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Published in:Sci Rep
Main Authors: Martin, Katrin, Reimann, Andreas, Fritz, Rafael D., Ryu, Hyunryul, Jeon, Noo Li, Pertz, Olivier
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766498/
https://ncbi.nlm.nih.gov/pubmed/26912264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21901
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