Novel loci and pathways significantly associated with longevity

Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chi...

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Vydáno v:Sci Rep
Hlavní autoři: Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, Vaupel, James W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766491/
https://ncbi.nlm.nih.gov/pubmed/26912274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21243
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