Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting

The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the d...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Yin, Xian-Zhen, Wu, Li, Li, Ying, Guo, Tao, Li, Hai-Yan, Xiao, Ti-Qiao, York, Peter, Nangia, Ashwini, Gui, Shuang-Ying, Zhang, Ji-Wen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766417/
https://ncbi.nlm.nih.gov/pubmed/26911359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21770
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