Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson...

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Published in:Nat Commun
Main Authors: Sant'Anna, Ricardo, Gallego, Pablo, Robinson, Lei Z., Pereira-Henriques, Alda, Ferreira, Nelson, Pinheiro, Francisca, Esperante, Sebastian, Pallares, Irantzu, Huertas, Oscar, Rosário Almeida, Maria, Reixach, Natàlia, Insa, Raul, Velazquez-Campoy, Adrian, Reverter, David, Reig, Núria, Ventura, Salvador
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766415/
https://ncbi.nlm.nih.gov/pubmed/26902880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10787
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