Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Sant'Anna, Ricardo, Gallego, Pablo, Robinson, Lei Z., Pereira-Henriques, Alda, Ferreira, Nelson, Pinheiro, Francisca, Esperante, Sebastian, Pallares, Irantzu, Huertas, Oscar, Rosário Almeida, Maria, Reixach, Natàlia, Insa, Raul, Velazquez-Campoy, Adrian, Reverter, David, Reig, Núria, Ventura, Salvador
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766415/
https://ncbi.nlm.nih.gov/pubmed/26902880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10787
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