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Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review

BACKGROUND: Personalized medicine is a growing area of research which aims to tailor the treatment given to a patient according to one or more personal characteristics. These characteristics can be demographic such as age or gender, or biological such as a genetic or other biomarker. Prior to utiliz...

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Bibliographic Details
Published in:PLoS One
Main Authors: Antoniou, Miranta, Jorgensen, Andrea L, Kolamunnage-Dona, Ruwanthi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766245/
https://ncbi.nlm.nih.gov/pubmed/26910238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149803
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