Retigabine, a K(v)7.2/K(v)7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations

The hetero-tetrameric voltage-gated potassium channel K(v)7.2/K(v)7.3, which is encoded by KCNQ2 and KCNQ3, plays an important role in limiting network excitability in the neonatal brain. K(v)7.2/K(v)7.3 dysfunction resulting from KCNQ2 mutations predominantly causes self-limited or benign epilepsy...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ihara, Yukiko, Tomonoh, Yuko, Deshimaru, Masanobu, Zhang, Bo, Uchida, Taku, Ishii, Atsushi, Hirose, Shinichi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766199/
https://ncbi.nlm.nih.gov/pubmed/26910900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150095
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