Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation and Protein-ligand X-ray Studies

Structure-based design, synthesis, and biological evaluation of a series of very potent HIV-1 protease inhibitors are described. In an effort to improve backbone ligand-binding site interactions, we have incorporated basic-amines at the C4 position of the bis-tetrahydrofuran (bis-THF) ring. We specu...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Ghosh, Arun K., Martyr, Cuthbert D., Osswald, Heather L., Sheri, Venkat Reddy, Kassekert, Luke A., Chen, Shujing, Agniswamy, Johnson, Wang, Yuan-Fang, Hayashi, Hironori, Aoki, Manabu, Weber, Irene T., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765732/
https://ncbi.nlm.nih.gov/pubmed/26306007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00900
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