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Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson’s disease

Parkinson’s disease (PD) is a severe neurodegenerative disorder without effective treatments. Here, we present a novel drug repositioning approach to predict new drugs for PD leveraging both disease genetics and large amounts of mouse model phenotypes. First, we identified PD-specific mouse phenotyp...

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Podrobná bibliografie
Vydáno v:AMIA Annu Symp Proc
Hlavní autoři: Chen, Yang, Cai, Xiaoshu, Xu, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Informatics Association 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765695/
https://ncbi.nlm.nih.gov/pubmed/26958284
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