TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL

Early diagnosis of CTCL is difficult and takes on average six years after presentation, in part because the clinical appearance and histopathology of CTCL can resemble that of benign inflammatory skin diseases. Detection of a malignant T cell clone is critical in making the diagnosis of CTCL but the...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Kirsch, Ilan R., Watanabe, Rei, O'Malley, John T., Williamson, David W., Scott, Laura-Louise, Elco, Christopher P., Teague, Jessica E., Gehad, Ahmed, Lowry, Elizabeth L., LeBoeuf, Nicole R., Krueger, James G., Robins, Harlan S., Kupper, Thomas S., Clark, Rachael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765389/
https://ncbi.nlm.nih.gov/pubmed/26446955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa9122
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