Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro

BACKGROUND: Aquaporins (AQP) are water channel proteins that enable fluid fluxes across cell membranes, important for homeostasis of the tissue environment and for cell migration. AQP1 knockout mouse models of human cancers showed marked inhibition of tumor-induced angiogenesis, and in pre-clinical...

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Foilsithe in:J Exp Clin Cancer Res
Main Authors: Dorward, Hilary S., Du, Alice, Bruhn, Maressa A., Wrin, Joseph, Pei, Jinxin V., Evdokiou, Andreas, Price, Timothy J., Yool, Andrea J., Hardingham, Jennifer E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2016
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765103/
https://ncbi.nlm.nih.gov/pubmed/26912239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0310-6
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