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Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway

BACKGROUND: The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. At the level of the genome, GLI factors bind to specific motifs in enhancers, so...

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Detalhes bibliográficos
Publicado no:BMC Dev Biol
Main Authors: Gurdziel, Katherine, Vogt, Kyle R., Schneider, Gary, Richards, Neil, Gumucio, Deborah L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765071/
https://ncbi.nlm.nih.gov/pubmed/26912062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12861-016-0106-0
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