Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment

Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths. Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotransporter, has been proposed as a cause of PAM. We...

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Publicado no:Sci Transl Med
Main Authors: Saito, Atsushi, Nikolaidis, Nikolaos M., Amlal, Hassane, Uehara, Yasuaki, Gardner, Jason C., LaSance, Kathleen, Pitstick, Lori B., Bridges, James P., Wikenheiser-Brokamp, Kathryn A., McGraw, Dennis W., Woods, Jason C., Sabbagh, Yves, Schiavi, Susan C., Altinişik, Göksel, Jakopović, Marko, Inoue, Yoshikazu, McCormack, Francis X.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764987/
https://ncbi.nlm.nih.gov/pubmed/26560359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8577
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