Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome

When retinoic acid-inducible gene 1 protein (RIG-I)-like receptors sense viral dsRNA in the cytosol, RIG-I and melanoma differentiation-associated gene 5 (MDA5) are recruited to the mitochondria to interact with mitochondrial antiviral signaling protein (MAVS) and initiate antiviral immune responses...

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Publicado no:Sci Rep
Main Authors: Cao, Zhongying, Zhou, Yaqin, Zhu, Shengli, Feng, Jian, Chen, Xueyuan, Liu, Shi, Peng, Nanfang, Yang, Xiaodan, Xu, Gang, Zhu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764940/
https://ncbi.nlm.nih.gov/pubmed/26906558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22002
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