TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

ERBB2 overexpression in human breast cancer leads to invasive carcinoma but the mechanism is not clearly understood. Here we report that TOM1L1 is co-amplified with ERBB2 and defines a subgroup of HER2(+)/ER(+) tumours with early metastatic relapse. TOM1L1 encodes a GAT domain-containing trafficking...

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Udgivet i:Nat Commun
Main Authors: Chevalier, Clément, Collin, Guillaume, Descamps, Simon, Touaitahuata, Heiani, Simon, Valérie, Reymond, Nicolas, Fernandez, Laurent, Milhiet, Pierre-Emmanuel, Georget, Virginie, Urbach, Serge, Lasorsa, Laurence, Orsetti, Béatrice, Boissière-Michot, Florence, Lopez-Crapez, Evelyne, Theillet, Charles, Roche, Serge, Benistant, Christine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764922/
https://ncbi.nlm.nih.gov/pubmed/26899482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10765
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