A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈1000 from Xenopus ooc...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Kırlı, Koray, Karaca, Samir, Dehne, Heinz Jürgen, Samwer, Matthias, Pan, Kuan Ting, Lenz, Christof, Urlaub, Henning, Görlich, Dirk
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764573/
https://ncbi.nlm.nih.gov/pubmed/26673895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11466
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