Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption....

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Erjavec, Igor, Bordukalo-Niksic, Tatjana, Brkljacic, Jelena, Grcevic, Danka, Mokrovic, Gordana, Kesic, Maja, Rogic, Dunja, Zavadoski, William, Paralkar, Vishwas M., Grgurevic, Lovorka, Trkulja, Vladimir, Cicin-Sain, Lipa, Vukicevic, Slobodan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764355/
https://ncbi.nlm.nih.gov/pubmed/26907598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150102
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