Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption....

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Veröffentlicht in:PLoS One
Hauptverfasser: Erjavec, Igor, Bordukalo-Niksic, Tatjana, Brkljacic, Jelena, Grcevic, Danka, Mokrovic, Gordana, Kesic, Maja, Rogic, Dunja, Zavadoski, William, Paralkar, Vishwas M., Grgurevic, Lovorka, Trkulja, Vladimir, Cicin-Sain, Lipa, Vukicevic, Slobodan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764355/
https://ncbi.nlm.nih.gov/pubmed/26907598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150102
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