3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

Most mammalian genes often feature alternative polyadenylation (APA) sites and hence diverse 3’UTR lengths. Proliferating cells were reported to favor APA sites that result in shorter 3’UTRs. One consequence of such shortening is escape of mRNAs from targeting by microRNAs (miRNAs) whose binding sit...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Hoffman, Yonit, Bublik, Debora Rosa, P. Ugalde, Alejandro, Elkon, Ran, Biniashvili, Tammy, Agami, Reuven, Oren, Moshe, Pilpel, Yitzhak
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764332/
https://ncbi.nlm.nih.gov/pubmed/26908102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005879
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