3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

Most mammalian genes often feature alternative polyadenylation (APA) sites and hence diverse 3’UTR lengths. Proliferating cells were reported to favor APA sites that result in shorter 3’UTRs. One consequence of such shortening is escape of mRNAs from targeting by microRNAs (miRNAs) whose binding sit...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Hoffman, Yonit, Bublik, Debora Rosa, P. Ugalde, Alejandro, Elkon, Ran, Biniashvili, Tammy, Agami, Reuven, Oren, Moshe, Pilpel, Yitzhak
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764332/
https://ncbi.nlm.nih.gov/pubmed/26908102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005879
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