3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

Most mammalian genes often feature alternative polyadenylation (APA) sites and hence diverse 3’UTR lengths. Proliferating cells were reported to favor APA sites that result in shorter 3’UTRs. One consequence of such shortening is escape of mRNAs from targeting by microRNAs (miRNAs) whose binding sit...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hoffman, Yonit, Bublik, Debora Rosa, P. Ugalde, Alejandro, Elkon, Ran, Biniashvili, Tammy, Agami, Reuven, Oren, Moshe, Pilpel, Yitzhak
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764332/
https://ncbi.nlm.nih.gov/pubmed/26908102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005879
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