Combined loss of Tet1 and Tet2 promotes B-cell, but not myeloid malignancies in mice

TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2-deletion in mice causes myeloid malignancies, while Tet1-null mice develop B-cell lymphoma after an extended period o...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764044/
https://ncbi.nlm.nih.gov/pubmed/26586431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.037
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料