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Low-density lipoprotein receptor-related protein 1 mediates α1-antitrypsin internalization in CD4(+) T lymphocytes
In α1-antitrypsin–deficient HIV patients, an accelerated decline of CD4(+) T cell numbers is observed, suggesting that α1-antitrypsin is a potential endogenous HIV inhibitor. In infected T lymphocytes, α1-antitrypsin potently blocks NF-κB activation and HIV-1 replication by directly interacting with...
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| Gepubliceerd in: | J Leukoc Biol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Society for Leukocyte Biology
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4763795/ https://ncbi.nlm.nih.gov/pubmed/26206901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A0515-209R |
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