Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

Recent genomic studies challenge the conventional model that each metastasis must arise from a single tumor cell and instead reveal that metastases can be composed of multiple genetically distinct clones. These intriguing observations raise the question: How do polyclonal metastases emerge from the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cheung, Kevin J., Padmanaban, Veena, Silvestri, Vanesa, Schipper, Koen, Cohen, Joshua D., Fairchild, Amanda N., Gorin, Michael A., Verdone, James E., Pienta, Kenneth J., Bader, Joel S., Ewald, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763783/
https://ncbi.nlm.nih.gov/pubmed/26831077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508541113
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