ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

Breast cancer progression involves genetic changes and changes in the extracellular matrix (ECM). To test the importance of the ECM in tumor cell dissemination, we cultured epithelium from primary human breast carcinomas in different ECM gels. We used basement membrane gels to model the normal micro...

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Detalhes bibliográficos
Main Authors: Nguyen-Ngoc, Kim-Vy, Cheung, Kevin J., Brenot, Audrey, Shamir, Eliah R., Gray, Ryan S., Hines, William C., Yaswen, Paul, Werb, Zena, Ewald, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465416/
https://ncbi.nlm.nih.gov/pubmed/22923691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212834109
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