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miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells

We report on the properties and function of two herpes simplex virus-1 (HSV-1) microRNAs (miRNAs) designated “miR-H28” and “miR-H29.” Both miRNAs accumulate late in productive infection at a time when, for the most part, viral DNA and proteins have been made. Ectopic expression of miRNA mimics in hu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Han, Zhiyuan, Liu, Xianjie, Chen, Xiaoqing, Zhou, Xusha, Du, Te, Roizman, Bernard, Zhou, Guoying
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763765/
https://ncbi.nlm.nih.gov/pubmed/26831114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525674113
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