Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus

Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1. Conventionally, only antibodies targeting these molecules have been thought to contribute to disease pathogene...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sajda, Thomas, Hazelton, Julian, Patel, Milan, Seiffert-Sinha, Kristina, Steinman, Lawrence, Robinson, William, Haab, Brian B., Sinha, Animesh A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763733/
https://ncbi.nlm.nih.gov/pubmed/26831096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525448113
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