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Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

Liver dysfunction is an early event in sepsis-related multi-organ failure. We here report the establishment and characterization of a microfluidically supported in vitro organoid model of the human liver sinusoid. The liver organoid is composed of vascular and hepatocyte cell layers integrating non-...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Gröger, Marko, Rennert, Knut, Giszas, Benjamin, Weiß, Elisabeth, Dinger, Julia, Funke, Harald, Kiehntopf, Michael, Peters, Frank T., Lupp, Amelie, Bauer, Michael, Claus, Ralf A., Huber, Otmar, Mosig, Alexander S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763209/
https://ncbi.nlm.nih.gov/pubmed/26902749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21868
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