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CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model

Sepsis is a leading cause of mortality in the critically ill, characterized by life-threatening organ dysfunctions due to dysregulation of the host response to infection. Using mass spectrometry, we identified a C-terminal fragment of alpha-1-antitrypsin, designated CAAP48, as a new sepsis biomarker...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Blaurock-Möller, Nancy, Gröger, Marko, Siwczak, Fatina, Dinger, Julia, Schmerler, Diana, Mosig, Alexander S., Kiehntopf, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401602/
https://ncbi.nlm.nih.gov/pubmed/30873161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00273
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