Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and t...

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發表在:Stem Cells Int
Main Authors: Hermann, Andreas, Kim, Jeong Beom, Srimasorn, Sumitra, Zaehres, Holm, Reinhardt, Peter, Schöler, Hans R., Storch, Alexander
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763001/
https://ncbi.nlm.nih.gov/pubmed/26977154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4736159
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