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Senescence impairs direct conversion of human somatic cells to neurons
Recent reports have shown that fibroblasts can be converted to neurons by forced expression of transcription factors. However, the mechanisms underlying this conversion remain unclear. Here, we show that the efficiency of neuronal conversion of embryonic human fibroblasts aged in culture is lower th...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4762026/ https://ncbi.nlm.nih.gov/pubmed/24934763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5112 |
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