Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.

In the biosynthetic pathway of tropane alkaloids, tropinone reductase (EC 1.1.1.236) (TR)-I and TR-II, respectively, reduce a common substrate, tropinone, stereospecifically to the stereoisomeric alkamines tropine and pseudotropine (psi-tropine). cDNA clones coding for TR-I and TR-II, as well as a s...

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Autores principales: Nakajima, K, Hashimoto, T, Yamada, Y
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC47615/
https://ncbi.nlm.nih.gov/pubmed/8415746
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