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NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection
Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity antibodies. Here we show that deficiency in NFAT1 and NFAT2 in CD4(+) T cells leads to impaired germinal center reactions upon vir...
Shranjeno v:
| izdano v: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4761453/ https://ncbi.nlm.nih.gov/pubmed/26851216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501841 |
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