C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells

Amongst several genetic mutations known to cause amyotrophic lateral sclerosis (ALS), a hexanucleotide repeat expansion in the C9orf72 gene is the most common. In approximately 30% of C9orf72-ALS cases, 5-methylcytosine (5mC) levels within the C9orf72 promoter are increased, resulting in a modestly...

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Bibliographic Details
Published in:Exp Neurol
Main Authors: Esanov, Rustam, Belle, Kinsley C., van Blitterswijk, Marka, Belzil, Veronique V., Rademakers, Rosa, Dickson, Dennis W., Petrucelli, Leonard, Boylan, Kevin B., Dykxhoorn, Derek M., Wuu, Joanne, Benatar, Michael, Wahlestedt, Claes, Zeier, Zane
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761318/
https://ncbi.nlm.nih.gov/pubmed/26746986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.12.022
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