IL-21 and Probiotic Therapy Improve T(H)17 Frequencies, Microbial Translocation, and Microbiome in ARV-Treated, SIV-Infected Macaques

Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been attributed to persistent immune dysfunction, in part due to abnormalities at the gastrointestinal barrier. In particular, the poor reconstitution of gastrointestinal T(H)17 cells correlates with residual transloca...

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Veröffentlicht in:Mucosal Immunol
Hauptverfasser: Ortiz, Alexandra M., Klase, Zachary A., DiNapoli, Sarah R., Vujkovic-Cvijin, Ivan, Carmack, Kirby, Perkins, Molly R., Calantone, Nina, Vinton, Carol L., Riddick, Nadeene E., Gallagher, John, Klatt, Nichole R., McCune, Joseph M., Estes, Jacob D., Paiardini, Mirko, Brenchley, Jason M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760912/
https://ncbi.nlm.nih.gov/pubmed/26286233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.75
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